Mon. Oct 2nd, 2023
Matching drugs to DNA is 'new era of medicine

We have the technology to usher in a new era in medicine by integrating medicines precisely into people’s genetic codes,” a major report said.

Some types of medicine are completely ineffective and become deadly because of subtle differences in how our bodies function.

The British Pharmacological Society and the Royal College of Physicians say that genetic testing can determine how well a drug works in your body.

These tests may be available on the NHS next year. Your genetic code or DNA is a guide to how your body works. The field of medicine that matches your DNA is known as pharmacogenomics.

This would have helped Liverpool’s Jane Burns, who lost two-thirds of her skin after reacting badly to a new epilepsy drug.

When she was 19, she was given carbamazepine. Two weeks later, he developed a seizure and his parents took him to A&E when he developed a high fever and became ill. The next morning the skin damage started. Jane told CNN: “I remember waking up and I was just covered in blisters. It was like a horror movie, I felt like I was burning in the fire.”

Her epilepsy medication caused Stevens-Johnson syndrome, which affects the skin and is more likely to occur in people who are born with certain mutations in their genetic code.

Mrs. Burns said she was “extremely, very fortunate” and said she supported pharmacogenomic tests.

“If it saves your life, it’s a wonderful thing.”

Almost everyone is affected. Gene experimentation may seem rare, but Professor Mark Crowfield, who was elected president of the British Pharmacological Society, said: So it won’t work. Or it will hurt.

Jane Burns, now 50, has to be careful in the sun and is "terrified" of taking new medicines

” half a million more than people in the UK do not get better relief from codeine pain. Their genetic code does not contain instructions for making enzymes that break down codeine into morphine, and without it, the drug is ineffective.

The genetic code of one in 500 If they take the antibiotic gentamicin they are at higher risk of hearing loss.

Pharmacogenomics is already used for some medicines. In the past, 5-7% of people had a bad reaction to the HIV drug Abacavir and some died. Testing people’s DNA before prescribing medicine means the risk is now zero.

Scientists have looked at the 100 most recommended medicines in the UK. “We already have the technology to initiate genetic testing to guide the use of 40 of them,” the report said.

Genetic analysis will cost about £ 100 and can be done using a blood or saliva sample.


Initially, the approach is to perform the test when one of the 40 medications is prescribed. In the long run, the desire is to get well tested ahead of time – possibly at birth if the newborn’s genetic testing continues, or as part of a routine checkup in your 50s.

related to health Professor Sir Munir Pir Mohammad said, “We need to move beyond ‘one medicine and one food fits all’ to a more personal approach, where patients need to improve the effectiveness and safety of medicines. Therefore, the right medicine is given at the right dose, “said Prof. Sir Munir Pir Mohammad. The University of Liverpool.


” which we are doing is moving into a new era of medicine, because we’re all individuals and we’re all different in the way we respond to drugs.”

“when our age goes to up word and more and more medications are prescribed, there is a 70% chance that by the age of 70 you will be using at least one drug that will help your genetic makeup,” he said. Be inspired by you

“It will revolutionize medicine,” said Lord David Prior, chairman of the NHS England.

“Pharmacogenomics is the future,” they said, “and it can now help us new deliver, innovative personalized healthcare system for 2022.”

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